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Abstract: Epigenetics plays an important role in the process of biological adaptation to the environment. After the body is exposed to high temperature, epigenetics plays protective effects through three aspects: (1) produces phenotypes that can adjust the internal environment in time, such as high expression of heat shock proteins, to maintain the bodys homeostasis; (2) keeps the body in a “warning state”, to quickly respond to thermal stimuli that may be faced again soon; (3)Inherits the memory of the “adaptive” phenotype to the offspring, and improve adaptability of offspring to thermal stimuli. This review aims to review the related research on epigenetics in heat injury diseases in recent years, hoping to provide some ideas for research progress of heat related diseases.

Key words: epigenetics, heat injury disease, heat stroke