钠-葡萄糖协同转运蛋白2 抑制剂的心血管保护机制及临床研究进展

doi:10.3969/j.issn.1006298X.2022.04.013

肾脏病与透析肾移植杂志 ›› 2022, Vol. 31 ›› Issue (4): 357-362.DOI: 10.3969/j.issn.1006298X.2022.04.013

钠-葡萄糖协同转运蛋白2 抑制剂的心血管保护机制及临床研究进展

出版日期:2022-08-29 发布日期:2022-08-26

Mechanisms and clinical research of cardio-protective effects of sodium-glucose cotransporter 2 inhibitors

Online:2022-08-29 Published:2022-08-26

摘要/Abstract

摘要： 除了降糖作用,钠葡萄糖协同转运蛋白2抑制剂还有利尿利钠、减轻心脏负荷、改善心肌能量代谢和功能、改善血管内皮功能等心血管保护作用。近年来,多项大规模随机对照试验结果也证实,此类药物除延缓慢性肾脏病进展,还可显著降低动脉粥样硬化事件、心力衰竭住院、心血管和总体死亡率。

关键词: 钠-葡萄糖协同转运蛋白2抑制, 剂心血管保护, 临床研究

Abstract:

Sodiumglucose cotransporter 2 inhibitor as a new hypoglycemic drug is available in Chinese market. In addition to its hypoglycemic effect, it has effect of cardiovascular protection, such as diuresis and natriuresis, which can relieve heart load, improve myocardial energy metabolism and vascular endothelial function. In recent years, several largescale randomized controlled trials have also confirmed that such drugs can significantly reduce the risk of atherosclerotic events, heart failure hospitalization, cardiovascular and total mortality, and delay the progression of chronic kidney disease.

Key words: sodium-glucose cotransporter 2 inhibitors, cardio-protective effect, sclinical research

陈佩玲, 杨柳, 安玉, 章海涛. 钠-葡萄糖协同转运蛋白2 抑制剂的心血管保护机制及临床研究进展[J]. 肾脏病与透析肾移植杂志, 2022, 31(4): 357-362.

CHEN Peiling, YANG Liu, AN Yu, ZHANG Haitao. Mechanisms and clinical research of cardio-protective effects of sodium-glucose cotransporter 2 inhibitors[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2022, 31(4): 357-362.

ISSN 1006-298X CN 32-1425/R

钠-葡萄糖协同转运蛋白2 抑制剂的心血管保护机制及临床研究进展

Mechanisms and clinical research of cardio-protective effects of sodium-glucose cotransporter 2 inhibitors

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价