关键词: 肾移植,扩大标准供者,LifePort,器官保存,移植肾功能延迟恢复

Abstract: Ｏｂｊｅｃｔｉｖｅ：Due to the shortage of kidney donors, extended criteria donor (ECD) has been widely used in clinical practice, and hypothermic machinical perfusion for organ preservation has been given more attention. To study and analyze the effect of donation after cardiac death (DCD) marginal donor after Hypothermic machineperfusion on the early recovery of renal function in recipients after renal transplantation.
Ｍｅｔｈｏｄｏｌｏｇｙ：Peoples hospital of Zhengzhou organ transplantation center from January 2016 to January 2019 finished edges of ECD transplantation 120 cases, randomly to one side each donor kidneys and kidney with LifePort continued low perfusion (LifePort group, n=120), another side kidney use low temperature static preservation (low temperature static group, n=120), and then on the allograft kidney transplant, early postoperative observation group 2 recipients transplanted kidney index, survival rate, complications occurred.
Ｒｅｓｕｌｔｓ：In the absence of postoperative DGF, the two groups of recipients returned to normal and remained at a stable level about 2 weeks after the operation. Compared with the lowtemperature static group, the mean Scr in the LifePort group was significantly lower than that in the lowtemperature static group (11418±1440 μmol／L) at discharge, and the difference was statistically significant (P=0025). There was no significant difference in serum creatinine values between the two groups at 1 month, 3 months, 6 months and 1 year after surgery (P>005). At 1 year after surgery, the survival rate of the LifePort group was 991％ (119／120), higher than that of the hypothermic static group (975％, 117／120), but the difference between the two groups was not statistically significant (P=0097). The incidence of delayed graft function (DGF) in LifePort group was 108％ (13／120), which was significantly lower than that in the hypothermic static group (225％,27／120), and the difference between the two groups was statistically significant (P=0024). There were no statistically significant differences in the incidence of postoperative acute rejection, surgical complications and infection between the two groups (P>005).
Ｃｏｎｃｌｕｓｉｏｎ：The application of LifePort in DCD renal perfusion preservation can reduce the degree of ischemia reperfusion injury of the donor kidney, significantly reduce the incidence of DGF after transplantation, and the early urine volume and serum creatinine recovery level after transplantation are significantly superior to those of the donor kidney stored at low temperature, especially for marginal donors.

Key words: kidney transplantation, extended criteria donor, LifeP, ortorgan preservation, delayed graft function recovery