Abstract:

A 49yearold man presented with leg edema, malignant hypertension and skin thicking restricted to distal upper limbs and face. Urinalysis revealed proteinuria and microscopic hematuria. Blood tests demonstrated elevated serum creatinine, microangiopathic hemolytic anemia, thrombocytopenia, positive antinuclear antibody and hypocomplementaemia. Renal biopsy showed a typical histologic picture of thrombotic microangiopathy. Finally, the patient was diagnosed as scleroderma renal crisis.