Abstract:

To investigate the incidence of abdominal aortic calcification (AAC) in maintenance hemodialysis (MHD) patients,analyze the risk factors of AAC,and explore the relationship between the level of serum 25hydroxyvitamin D3 [25(OH)D3] and AAC Score.
Ｍｅｔｈｏｄｏｌｏｇｙ：A total of 182 patients with maintenance hemodialysis (MHD) were enrolled in the Blood Purification Center of the First Affiliated Hospital of Harbin Medical University from December 2015 to December 2016.The clinical and laboratory data were recorded.Lumbar lateral radiographs were used to examine the calcification of the abdominal aorta (AAC) in patients with semiquantitative scoringPatients were divided into calcification group and noncalcified group according to whether the abdominal aorta calcification was detected.The levels of serum 25(OH)D3 and the difference of clinical indexes were compared between the two groups.Multivariate logistic regression analysis was used to analyze the risk factors of AAC.The correlation between serum 25(OH)D3 levels and AAC scores was analyzed by Spearman correlation.
Ｒｅｓｕｌｔｓ：Calcification group 144 cases (791%),noncalcified group 38 cases (209%).The levels of 25(OH)D3 in the calcification group were significantly lower than those in the noncalcified group [(465±2053) ng/mL to (461±2611) ng/mL,P<001].The age,dialysis age,diabetes mellitus,Pi,calcium and phosphorus product,AKP,iPTH and TC were significantly higher in the calcified group than those in the noncalcified group (P<005)24h residual urine volume,25(OH)D3,diastolic blood pressure were significantly lower than noncalcified group (P<005).Multivariate logistic regression analysis showed that age,BMI,diabetes,Pi,iPTH,TC may be a risk factor for AAC24h residual urine volume,25(OH)D3 are protective factors.Spearman  correlation analysis showed a negative correlation between serum 25(OH)D3 levels and AAC scores in MHD patients.
Ｃｏｎｃｌｕｓｉｏｎ：The prevalence AAC in MHD patients is high,the occurrence of AAC is related to age,BMI,diabetes mellitus,Pi and iPTH,TC24h residual urine volume,25(OH)D3 are protective factors.Serum 25(OH)D3 levels were negatively correlated with AAC scores.