Abstract:

Fibroblast growth factor23 (FGF23) is recently identified as a regulator of calcium and phosphorus, its circulating level has impact on the prognosis of patients with chronic renal failure. Currently a variety of factors has been found to participate in the regulation of FGF23, it was wellknown that active vitamin D, phosphorus were involved in this process. Calcium, serum iron, parathyroid hormone, and other posttranslational modification were proved to take part in FGF23 regulation, but the exact mechanism remained to be elucidated. Research on the regulatory factors of FGF23 is of significantly clinical value on targeted therapy to reduce circulating FGF23 level and improving the prognosis of chronic renal failure.