Abstract:

Recently, C3a/C3aR axis in kidney diseases have been a concern among nephrologists. C3a and C3aR have been reported increased in the kidney of patients with renal diseases and correlated with clinical and pathological indexes. Recent studies suggested that, via engaging with C3aR, C3a could contribute to the development and progression of kidney diseases by inducing activation of target cells such as leukocytes, renal tubular epithelium cells, endothelial cells and expression of various inflammatory cytokines. However, the exact mechanism and pathological process remains to be elucidated. In this article we will describe the recent developments in this important area and focus on the role of C3a/C3aR in kidney diseases.