ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2016, Vol. 25 ›› Issue (4): 324-329.DOI: 10.3969/cndt.j.issn.1006-298X.2016.04.005

• 论文 • 上一篇    下一篇

狼疮性肾炎患者肾移植的远期预后

  

  • 出版日期:2016-08-28 发布日期:2016-08-31

Outcomes  of renal transplantation in patients with lupus nephritis

  • Online:2016-08-28 Published:2016-08-31

摘要:

目的:回顾性分析狼疮性肾炎(LN)患者肾移植的临床特点及远期预后。
方法:收集本中心1994年至2014年明确诊断为LN并进行肾移植手术患者的基线资料和随访资料,分析其临床特点,肾移植后LN再发及远期预后,并与原发病为非LN的肾移植患者进行比较。
结果:LN组18例患者肾移植术后中位随访时间为528个月,其中有3例发生终末期肾病(ESRD),无一例死亡,肾移植后1年、5年、10年肾脏生存率为100%、889%、833%;对照组72例原发病为非LN患者肾移植术后的中位随访时间为585个月,其中有10例患者发生ESRD,1例死亡,肾移植后1年、5年、10年肾脏生存率为100%、931%、889%;两组患者肾脏生存率无统计学差异。LN组有1例患者在肾移植术后LN再发,但患者肾脏生存率未受影响。
结论:LN患者肾移植的远期预后较好,肾移植手术对进入ESRD的LN患者是一个很好的选择。

Abstract:

Objective:To investigate the outcome and clinical features of renal transplantation (RT) for recipients with lupus nephritis (LN).
Methodology:From March 1994 to December 2014, eighteen LN patients received RT were enrolled into this retrospective study. 72 nonLN patients with RT were regarded as control. Their clinical features, recurrence and prognosis were analyzed and compared.
Results:They were 5 males and 13 females with an average age of (33±7) years old in LN patients with RT. The median followup time was 528 in lupus group and 585 months in control group respectively. Nobody was died in lupus group and only one was died in control group. The graft survival rates for lupus patients were 100%, 889% and 833% at 1, 5 and 10 years respectively, similar to the control survival rates of 100%, 931% and 889% (P=058). Recurrent LN was detected in one patient, but  did not lead to graft failure.
Conclusion:Longterm graft survivals were similar in LN and nonLN RT recipients. Renal transplant is an alternative therapy for ESRD in this population.