ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2016, Vol. 25 ›› Issue (1): 90-93.DOI: 10.3969/cndt.j.issn.1006-298X.2016.01.020

• 论文 • 上一篇    下一篇

IgG4相关性间质性肾炎合并意义未明的单克隆丙种球蛋白病

  

  • 出版日期:2016-02-26 发布日期:2016-02-04

IgG4related tubulointerstitial nephritiscomply with monoclonal gammopathy of undetermined significance

  • Online:2016-02-26 Published:2016-02-04

摘要:

急性肾损伤起病的老年男性患者,实验室检查发现血IgG4显著升高,免疫固定电泳见IgAλ型单克隆免疫球蛋白,但骨髓穿刺未见浆细胞异常增殖。肾间质大量浸润细胞,以浆细胞居多,符合间质性肾炎,免疫组化染色肾间质区域见较多IgG4阳性浆细胞,结合临床符合IgG4相关性间质性肾炎合并意义未明的单克隆免疫球蛋白病。

Abstract:

A 66yearold male patient presented with acute renal insufficiency. He had elevated IgG4 levels with monoclonal immunoglobulin IgAλ. A renal biopsy showed severe tubulointerstitial nephritis (TIN) with extensive infiltration of IgG4positive plasma cells, suggesting a diagnosis of IgG4related tubulointerstitial nephritis(IgG4related TIN) with monoclonal gammopathy of undetermined significance (MGUS).