关键词: 钠磷协同转运蛋白, 矿物质和骨代谢紊乱

Abstract:

Mineral and bone disorders (MBD) is a common complication of chronic kidney disease (CKD). Previous studies of CKD-MBD were mainly concentrated in calcium metabolism disorder, and have confirmed that the serum calcium levels of CKD patients were regulated by PTH and 1,25 (OH) 2VitD3. In recent years, it have been found that hyperphosphorus is obviously associated with vascular calcification and cardiovascular death risk in end stage renal disease patients. Inorganic phosphorus participates in the composition of cell structures and many important biological functions in the cells. It is actively transported in inverse electrochemical and potential gradient across the cell membrane, and by sodium phosphorus cotransporter (Npt) which in the plasma membrane utilize the free energy provided by Na+ concentration gradient as a driving force to increase the phosphorus intake. Now three types of Npt are isolated from the mammalian cells at least. Npt is an important transport protein to inorganic phosphorus in the body and is also expressed in the membrane of osteoblast and osteoclast. Through the research of Npt involved in phosphate metabolism regulatory mechanism, it may bring a new target for the treatment of CKD-MBD.

Key words: Sodium-Phosphate Cotransporter Proteins,  , CKD-MBD