Abstract: Apolipoprotein E (apoE) plays a key role in lipoprotein metabolism,its mutation can cause dysfunction in apoE structure,causes apoErelated glomerular disorders,such as apoE2 homozygote glomerulopathy and lipoprotein glomerulopathy (LPG).ApoE2 homozygote glomerulopathy was characterized histologically by glomerulosclerosis with marked infiltration of foam cells .Macrophages are not only involved in formation of foam cells,but also their dysfunction can lead to accumulation of lipoproteins in glomeruli,causing lipoprotein thrombi derived from macrophagesIn patients with apoE Toyonaka (Ser197Cys) combined with homozygous apoE2/2,nonimmune membranous nephropathylike features were observed in glomeruli.LPG is histologically characterized by lamellated lipoprotein thrombi that lack foam cells.Therefore,the understanding of apoE gene polymorphism and pathogenesis of apoErelated glomerular disorders can provide means for effective treatment and individualized drug treatment,and prevent development of chronic kidney disease.