ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2026, Vol. 35 ›› Issue (4): 369-373.DOI: 10.3969/j.issn.1006⁃298X.2026.04.014

• 肾脏病临床 • 上一篇    下一篇

B 细胞靶向治疗在老年肾脏病中的应用

  

  • 出版日期:2026-08-28 发布日期:2026-08-31

B⁃cell targeted therapy in elderly patients with kidney diseases

  • Online:2026-08-28 Published:2026-08-31

摘要:

在老龄化社会的背景下,老年肾脏病患者的诊断、分型和治疗也逐渐成为关注焦点。近年来,各类肾脏疾病指南均纳入新型的分子靶向治疗方案。但来自老年患者的研究证据相对较少。因此,结合老年肾脏病的流行病学特征,评估分子靶向治疗在老年人群中的疗效和安全性,推进疾病个体化治疗具有重要意义。本文以 B 细胞靶向治疗为主线,通过文献复习,综述该类疗法在老年肾脏病中的应用研究进展。 


关键词: 肾脏疾病, B 细胞耗竭疗法, 老年, 靶向治疗

Abstract: In today's aging society, the diagnosis, pathological typing and treatment of elderly patients with kidney disease have gradually become a focus of attention. In recent years, various clinical guidelines for kidney diseases have incorporated novel molecular targeted therapies. However, evidence from studies specifically targeting elderly patients remains relatively limited. Therefore, it is of great significance to evaluate the efficacy and safety of molecular targeted therapies in elderly patients based on the epidemiological characteristics of kidney diseases in elderly patients, and to advance personalized treatment approaches. This article focuses on B⁃cell depletion therapy and reviews the research progress of this therapy in the treatment of elderly patients with kidney diseases.