ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2023, Vol. 32 ›› Issue (3): 296-300.DOI: 10.3969/j.issn.1006-298X.2023.03.020

• • 上一篇    

化疗后急性肾损伤并发严重乳酸酸中毒

  

  • 出版日期:2023-06-28 发布日期:2023-07-01

Acute kidney injury and severe lactic acidosis after chemotherapy

  • Online:2023-06-28 Published:2023-07-01

摘要: 老年男性患者,2型糖尿病长期口服二甲双胍,因慢性粒细胞白血病,氟马替尼治疗后出现急性肾损伤3期、肿瘤溶解综合征,伴发严重乳酸酸中毒、白细胞淤滞症。停药并给予连续性静脉静脉血液滤过及补液等对症治疗后病情迅速逆转。


关键词: 急性肾损伤, 乳酸酸中毒, 白细胞淤滞症, 肿瘤溶解综合征

Abstract: A 74-year-old male with type 2 diabetes was treated with metformin. After taking flumatinib to treat chronic myeloid leukemia, he developed acute kidney injury and tumor lysis syndrome, and subsequently burst severe lactic acidosis and leukocytosis. The chaos was rapidly reversed after the drugs withdrawal and supportive treatments including continuous venous-venous hemofiltration and fluid infusion.


Key words: acute kidney injury, lactic acidosis, leukostasis, tumor lysis syndrome