肾脏病与透析肾移植杂志 ›› 2023, Vol. 32 ›› Issue (1): 60-63.DOI: 10.3969/j.issn.1006-298X.2023.01.013
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摘要： 泛素-蛋白酶体系统(UPS)是细胞内调控蛋白质降解的重要系统,参与细胞内80％以上蛋白质的降解,对维持细胞稳态和功能具有重要的作用。近年来,UPS与足细胞功能开始受到广泛关注。本文就目前UPS与足细胞损伤的研究进展作一综述。
关键词: 泛素, 蛋白酶体, 足细胞
Abstract: ＴUbiquitin-proteasome system (UPS) is essential for the regulation of various cellular functions by degradation of over 80％ of cellular proteins, and is critical for maintaining cellular homeostasis. Recently, increasing evidences emphasize the involvement and importance of UPS in physiological and pathophysiological processes during podocyte injury. In this review, we provide the overview of UPSmediated proteostasis in podocyte injury.
Key words: ubiquitin, proteasome, podocyte
侯庆, 刘志红. 泛素-蛋白酶体与足细胞损伤[J]. 肾脏病与透析肾移植杂志, 2023, 32(1): 60-63.
HOU Qing, LIU Zhihong. Ubiquitin-proteasome system and podocyte injury[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2023, 32(1): 60-63.
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链接本文: http://www.njcndt.com/CN/10.3969/j.issn.1006-298X.2023.01.013
http://www.njcndt.com/CN/Y2023/V32/I1/60
