Abstract:

ABSTRACT Objective: To compare the residual renal function (RRF) decline in peritoneal dialysis (PD) patients with different baseline residual renal function and explore its relative factors. Methodology: Two hundred one new PD patients were enrolled in this study. They were divided into three groups according to estimated glomerular filtration rate (eGFR)：group A was eGFR <6 ml/min (n=60), group B eGFR 6-10ml/min (n=91), and group C eGFR >10ml/min (n=50). During the follow up, we regularly examined laboratory measurements, and dialysis status was evaluated. The average rate of RRF decline was calculated in three groups after follow-up of 36 months. Results: The average rate of RRF decline was -0.089, -0.152, -0.247(ml/min/month) respectively on group A, group B and group C (P<0.001). By linear multiple regression analysis, the independent factors for the decline of RRF were cardiothoracic ratio (rs= -0.238) in group B, triglyceride (rs= -0.421), eGFR (rs= -0.557) and hemoglobin (rs= 0.216) in group C ( no independent factor was in group A ). At the end of follow-up, the average of RRF in group C was still maximum and the patients have no RRF with the lowest percentage among three groups (P <0.001), and their heart failure occurs later . Conclusion: The RRF declined fastest in the patients with highest baseline RRF, but they maintained the highest RRF at the end of follow-up and have no RRF with the lowest percentage among three groups.

Key words: peritoneal dialysis, residual renal function, decline rate, relative factors