Abstract:

Abstract Objective: To investigate the incidence of renal post-transplantation diabetes mellitus（PTDM）in our hospital, to compare it with other correlated studies domestically and overseas, to screen the related risk factors and to provide data for individual therapy after transplantation. Methodology: One hundred fifty five patients, 108 males and 47 females, were received allogeneic renal transplant surgery from October 2007 to April 2011 in our hospital. Among them, 128 patients who accorded the research criteria were enrolled into this study, and divided into two groups according to whether or not being diagnosed as PTDM. 51 patients were assigned to the group of PTDM and 77 patients were assigned to the group of none-PTDM (N-PTDM).Their clinical data including: age, body mass index (BMI), alcohol and tobacco history, family history, cholesterol, triglyceride, blood pressure, uric acid, whether if dialysis, the dialysis time, postoperative immunosuppressive monitoring and acute rejection, etc .were collected abd compared. Results: The PTDM incidence of post renal transplantation was 39.8% in our hospital. There were no statistical differences between the two groups in age, sex, BMI, blood pressure, blood lipids, blood uric acid and other basic treatment before operation (P > 0.05). Logistic regression analysis of single factor showed that the age, sex, BMI, blood pressure, blood fat , blood uric acid, and other factors had no correlation with PTDM (P>0.05). Whether if dialysis and the dialysis time also hadn’t correlation with PTDM (P>0.05).The immunosuppressive protocols using FK506 primarily and the acute rejection were significantly associated with PTDM (P<0.05). Multi-factors unconditional Logistic stepwise regression analysis also showed that the immunosuppressive protocols using FK506 primarily and the acute rejection were significantly associated with PTDM (P<0.05). Conclusion: The immunosuppressive protocols using FK506 primarily and the acute rejection were independent risk factors of PTDM post renal transplantation.

Key words: Renal transplantation, Post-transplantation diabetes mellitus, Risk factors