HLA-B*5801基因型与别嘌呤醇过敏反应

肾脏病与透析肾移植杂志 ›› 2014, Vol. 23 ›› Issue (6): 553-558.

HLA-B*5801基因型与别嘌呤醇过敏反应

出版日期:2014-12-28 发布日期:2014-12-31

HLA-B*5801 gene and allopurinol induced adverse reactions

Online:2014-12-28 Published:2014-12-31

摘要/Abstract

摘要：

摘要：别嘌呤醇是一种有效治疗高尿酸血症的药物，但存在发生严重皮肤过敏反应甚至死亡的风险。最近研究发现别嘌呤醇的过敏反应与HLA-B*5801密切相关，同时受到别嘌呤醇剂量、患者肾功能状态及是否合用噻嗪类利尿剂等因素影响。在使用前常规检测HLA-B*5801可以有效预防别嘌呤醇过敏反应的发生。本文综述了HLA-B*5801与别嘌呤醇过敏反应相关性的研究进展。

关键词: 别嘌呤醇, 过敏反应, HLA-B*5801

Abstract:

Abstract: Allopurinol is widely used for the treatment of hyperuricemia and gout, but severe cutaneous adverse reactions still happened to some patients and even is life-threaten. In recent years, many studies have found that there are very strong associations between allopurinol induced severe cutaneous adverse reactions and HLA-B*5801, and some studies also have found that the dose of allopurinol, the status of renal function, the usage of thiazide diuretics and so on may influence the adverse reactions. The test for HLA-B*5801 can prevent the occurrence of allopurinol induced cutaneous adverse reactions before using allopurinol. This article reviews the relationship between HLA-B*5801 and allopurinol.

Key words: allopurinol, cutaneous adverse reaction, HLA-B*5801

李康|胡伟新. HLA-B*5801基因型与别嘌呤醇过敏反应[J]. 肾脏病与透析肾移植杂志, 2014, 23(6): 553-558.

Li Kang|HU Weixin. HLA-B*5801 gene and allopurinol induced adverse reactions[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2014, 23(6): 553-558.

ISSN 1006-298X CN 32-1425/R