Abstract:

Abstract: Autosomal dominant polycystic kidney disease is the most common single-gene inherited kidney disease, it is characterized by kidney cysts and a range of extra-renal performance, due to its high incidence and poor prognosis，it becomes one of the most hot spots of the research in the field of nephrology. Its pathogenesis is not yet clear, it is generally believed ADPKD is caused by mutations in the gene PKD1, PKD2, abnormal cilia’s roles in pathogenesis is hot in recent research. In recent years, there were a number of related basic and clinical researches at home and abroad, which were progress in pathogenesis, diagnosis, and treatment emerges including the newly proposed pathogenesis such as the role of inflammation, as well as assessment of various diagnostic methods, applications of biomarkers, and discovery of new therapeutic targets. This paper briefly summaries the current research status and recent development.