关键词: 钙神经调节蛋白抑制剂, 狼疮性肾炎, 治疗, Meta分析

Abstract:

Ｏｂｊｅｃｔｉｖｅ：There is growing interest in the role of calcineurin inhibitors (CNIs) in lupus nephritis (LN) induction treatments.The study aimed to evaluate the efficacy and safety of CNIs as induction treatment for LN by metaanalysis.
Ｍｅｔｈｏｄｏｌｏｇｙ：PubMed,EMBASE,Cochrane Central Register of Controlled Trials (CENTRAL),and three Chinese databases (WanFang Data,Chongqing VIP and China National Knowledge Infrastructure) were searched for all human studies in induction  treatment of LN with CNIs up to September 2017.Randomized controlled trials (RCTs) comparing the efficacy and safety of CNIs with other drugs in LN patients were included.Statistical analyses were performed using Stata12 software.
Ｒｅｓｕｌｔｓ：A total of sixteen studies involving 871 patients were included in this study.CNIs had significant merits in increasing total remission (P＜0001) and complete remission (P＜0001).The incidences of infection,gastrointestinal discomfort,leukopenia and  menstrual disorder were higher in control group,whereas the incidences of hypertension,transient creatinine elevation and abnormal glucose metabolism were higher in CNIs group.
Ｃｏｎｃｌｕｓｉｏｎ：
Our systematic review demonstrates that CNIs are promising alternatives for LN patients,primarily due to their better shortterm efficacy and safety.Welldesigned clinical trials are needed to further evaluate the longterm efficacy and safety of CNIs.

Key words: calcineurin inhibitors, lupus nephritis, induction therapy, meta-analysis