Abstract:

There is increasing evidence pointing to that inflammation is a constant feature and a major mediator of the progression of chronic kidney disease (CKD). Many factors of CKDinduced systemic inflammation and oxidative stress have been explored. Recently, some studies have revealed the relationship between CKD and the dysfunction of intestinal microbiota and the impairment of intestinal epithelia barrier. Significant changes in the composition and function of intestinal bacterial flora are always found in CKD patients, as well as the impairment of the epithelia tight junction. And then, the increased intestinal permeability leads to the uremic toxins transferring to the circulation and systemic inflammation and oxidative stress, which causes the progress of CKD. Here, we will discuss the relationship between intestinal microbiota, intestinal epithelia barrier and CKD.