摘要：
肾脏中合成红细胞生成素（EPO）的细胞称为肾脏促红细胞生成素产生细胞（REPs），EPO生成不足会引起肾性贫血和慢性疾病相关性贫血。REPs可转分化成致瘢痕的肌成纤维细胞（MF），造成肾脏纤维化，在慢性肾脏病（CKD）患者中，REPs转分化成肌成纤维细胞（MFREPs）后产生EPO能力下降。近年来关于肾脏REPs的研究取得较大进展，对REPs的研究将有望成为治疗肾性贫血和肾间质纤维化的新靶点。
邵芳,谢红浪. 促红细胞生成素产生细胞与肾脏纤维化[J]. 肾脏病与透析肾移植杂志, 2017, 26(5): 471-475.
SHAO Fang,XIE Honglang. The cells which produced erythropoietin (EPO) in kidney is called renal EPOproducing cells (REPs). Insufficient production of EPO can cause renal anemia and anemia associated with chronic disease disorders. REPs transformed into scarforming myofibroblasts, resulting in renal fibrosis, chronic kidney disease (CKD) patients the EPOproducing ability of myofibroblasttransformed REPs (MFREPs) is decreased. Recently studies on REPs made great progress and the research is expected to become the treatment of renal anemia and renal interstitial fibrosis new target.[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2017, 26(5): 471-475.
