ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2016, Vol. 25 ›› Issue (6): 543-547.DOI: 10.3969/cndt.j.issn.1006-298X.2016.06.009

• 论文 • 上一篇    下一篇

壁层上皮细胞活化与肾小球疾病

  

  • 出版日期:2016-12-28 发布日期:2017-01-03

Activation of parietal epithelial cells and glomerular diseases

  • Online:2016-12-28 Published:2017-01-03

摘要:

针对肾小球固有细胞的研究,促进了肾小球疾病发病机制的了解。近年来,肾小球壁层上皮细胞(PECs)越来越受重视,PECs的正常生理功能和病理过程中的异常活化,与新月体、球性硬化等病变形成和转归有密切关系。本文将讨论PECs在维持肾小球正常结构功能中的作用,分析目前已知可能参与PECs活化过程中的信号通路及其在肾小球疾病中潜在机制。

Abstract:

In last decades, the attention was focused on the biology and role of glomerular resident cells in health and disease. More recently, the glomerular parietal epithelial cell (PEC) has been under active study, leading to a better understanding and definition of how these cells behave normally, and their potential roles in glomerular diseases. In current review, we will discuss latest observations and model systems to study PECs.