Abstract:

ABSTRACT: Protein-energy wasting (PEW), a term proposed by the International Society of Renal Nutrition and Metabolism (ISRNM), refers to the multiple nutritional and catabolic alterations that occur in chronic kidney disease (CKD) and is associated with morbidity and mortality. There are multiple factors related with PEW. Besides insufficient food intake (true under-nutrition) due to poor appetite and dietary restrictions, other factors such as inflammation, acidosis, endocrine disturbance are in charge of the more important problem, wasting. Because of unique dialysis mode, patients undergoing peritoneal dialysis have different characteristics of PEW. Multiple strategies are proposed to deal with PEW including nutrient supplement, modified PD dialysate, growth hormone, androgen, exercise and some new developed agents. This article reviews the etiology and treatment strategies of PEW in PD patients.

Key words: protein-energy wasting, chronic kidney disease, peritoneal dialysis