Abstract:

【Abstract】Objective: To investigate the risk factors of the first year mortality in patients with peritoneal dialysis (PD), and to explore the preventative ways. Methodplogy: The clinical data of two hundred forty eight PD patients in PD center from 2003 to 2014 were retrospectively reviewed. Among them, 18 patients died in one year after PD, and their risk factors were investigated. Results: The main cause of mortality was pulmonary infection (38.9%) and cardivascular event (27.8%). Compared with the living patients in one year, the patients died in one year were senior, and had more complications of diabetes, pulmonary infection and cardiovascular disease and more immunosuppressant utilization. Between the two groups, there were no significant differences in urine volume, HB, TC, HDL, LDL, TG, BUN, UA, Ca, P, iPTH, Weekly KT/V, Weekly Ccr, cardiothoracic ratio and ejection fraction. The eGFR and CRP were higher than control group, while the serum Alb、Scr、potassium(K+) were lower. According to logistic regression analysis, low serum Alb and high CRP were independent risk factors of first year mortality in PD patients. Conclusion: Advanced age, diabetes, pulmonary infection, cardiovascular disease, immunosupppressant utilization, hypokalemia should be risk factors in patients with peritoneal dialysis died in the first year. The Low-Alb and high CRP were the independent risk factors. To control infection and ameliorate hypokalemia, nutrition and micro-inflammatory state may be help to improve survival in patients undergoing peritoneal dialysis.

Key words: Peritoneal dialysis, malnutrition, micro-inflammatory state