Abstract:

ABSTRACT  Objective: To investigate the relationship of trascription factor 7 type 2 (TCF7L2) gene polymorphism with the risk of PTDM in Chinese renal allograft recipients. Methodology: A total of three hundred ninety eight unrelated renal allograft recipients without prior diabetes (97 patients with PTDM and 301 patients without PTDM) were genotyped for the presence of TCF7L2 gene rs290487 polymorphism by real-time fluorescence polymerase chain reaction (real-time PCR). Logistic regression method was used to identify risk factors for PTDM development and calculate the odds ratio (OR). Results: The genotype distributions of rs290487 were significantly different between the PTDM patients and controls (P <0.05). The effect of genotype remained significant (CC vs TT, OR=2.300, 95% CI : 1.196-4.425, P = 0.013; CC+CT vs TT, OR=1.935, 95% CI: 1.141-3.281, P =0.014) after adjustments for age, sex, body weight and body mass index (BMI). Conclusions: The C-allele in rs290487 of TCF7L2 is the independent risk factors of PTDM in Chinese renal allograft recipients.

Key words: KEY WORDS , Renal allograft recipients, Posttransplantation diabetes mellitus, TCF7L2 gene, rs290487, Single nucleotide polymorphism (SNP) , Risk factor