Abstract:

 ABSTRACT     A 46-year-old male was characterized by anemia, hyperviscosity syndrome, renal failure, increased immunoglobulin IgM, and serum κ IgM monoclonal component. Bone marrow biopsies indicated Waldenstrom macroglobulinemia. Renal biopsy showed diffuse tubular atrophy, tubular basement membrane thickening and focal interstitial infiltration of eosinophils with unremarkable glomerular lesion. Immunofluorescence revealed linear staining for κ light chain along glomerular capillary wall, tubular basement membrane, and blood vessel wall, and all of negative for IgG, IgA, IgM, C3, and C1q. Electron microscopy showed punctate electron dense deposits along glomerular capillary wall, the Bowman capsule wall, tubular basement membrane and vessel wall. The final diagnosis was κ light chain deposition disease associated with Waldenström macroglobulinemia accompanied with acute interstitial nephritis.

Key words: Waldenström macroglobulinemia , light chain deposition disease , Renal biopsy