Abstract:

ABSTRACT   Objective: To investigate the incidence and the rick factors of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography (CAG) and percutaneous coronary intervention (PCI). Methodology: From October 2010 to April 2011, a total of six hundred and seventy two cases undergoing CAG and PCI were recruited. CIN is identified if the serum creatinine is increased by 25% or 44.2μmol/L (0.5 mg/dl) of the baseline at 48 hours post procedure. The incidence and the rick factors of CIN were analyzed. Results: Of six hundred and seventy two patients, 292 cases (43.5%) were aged over ≥65, 588 (87.5%) had coronary heart disease, 461 (68.6%）had hypertension, 144 (21.4%) had diabetes mellitus, 30 (4.5%) had SCr more than 110μmol/L before procedure, 42 (6.3%) had anemia, 344 (51.2%) took ACEI, 95 (14.1%) took diuretics, 39 (5.8%) took metformins, and 237 cases (35.3%) had the volume of contrast media ≥200ml. Among the 672 patients, CIN occurred in 55 patients and the incidence of CIN was 8.2%.There were significant differences between CIN and non-CIN patients in terms of ages over 65, coronary heart disease, the volume of contrast meida ≥200ml. diuretics（P<0.05）. Logistic regression analysis showed that age ≥65, and the voluem of contrast media ≥200ml were independent risk factors of CIN. Conclusion: The incidence of CIN in patients undergoing CAG and PCI was higher. The age ≥65 and the volume of contrast meida ≥200ml were independent risk factors of CIN.

Key words: percutaneous coronary intervention  , contrast-induced nephropathy  , risk factor