Abstract: Dialysis⁃related amyloidosis is a long⁃term complication of maintenance hemodialysis, which seriously affects the quality of life and dialysis of MHD patients. The treatment should focus on prevention, and there is a lack of effective treatment. Common dialysis methods such as high⁃flux hemodialysis and hemodiafiltration have uncertain therapeutic effects. Expanded hemodialysis (HDx) is a novel hemodialysis mode that uses medium cut⁃off membranes. Its economic cost is lower than that of hemodiafiltration. It can better remove medium and large molecular toxins such as β₂-MG and improve the microinflammatory state of MHD patients, providing a theoretical basis for the prevention of DRA. This article reviews the pathogenesis of dialysis⁃related amyloidosis, and the theoretical basis and advantages of HDx in treating DRA.

Key words: font-family:Inter, -apple-system, BlinkMacSystemFont, ", font-size:16px, background-color:#F9FAFB, ">expanded hemodialysis, medium cut?off hemodialysis, maintenance hemodialysis, dialysis?related amyloidosis