Abstract: Diabetic nephropathy (DN) is the most prevalent complication of type 2 diabetes mellitus, and is characterized by a complex pathogenesis. Post-translational modifications (PTM) refer to the processes by which chemical groups are covalently added to proteins following synthesis, thereby altering their structure and function. These modifications include acetylation, malonylation, succinylation, lactylation, among others. The PTMs of key proteins can significantly influence cellular metabolic reprogramming and critical signaling pathways, participating processes such as signal transduction, cycle regulation, and metabolic regulation. An increasing body of research has demonstrated that multiple PTMs play significant roles in the pathological processes of DN, including injury to intrinsic renal cells and tubulointerstitial fibrosis. This article reviews the research progress regarding the relationship between PTM and DN.

Key words: font-family:Inter, -apple-system, BlinkMacSystemFont, ", font-size:16px, background-color:#F9FAFB, ">post-translational modification, diabetic nephropathy, acetylation, malonylation, succinylation, lactylation