Abstract: Ｏｂｊｅｃｔｉｖｅ：To design a reusable device for continuous multiple measurement of intraperitoneal pressure in peritoneal dialysis patients, and to evaluate the feasibility and safety of the application of the method.
Ｍｅｔｈｏｄｏｌｏｇｙ：The designed measuring device is composed of a U-shaped pressure gauge, a plastic hose with clamps and an air pressure sensor protector. The device is connected to the external pipe of abdominal dialysis and the double bag of abdominal dialysis liquid through the medical extension pipe and the medical three-way stopcock. The three-way stopcock is rotated to realize the quantitative injection of abdominal dialysis liquid and the measurement of abdominal pressure. The pressure measuring port of the device was connected to the invasive blood pressure measuring terminal of the mercury sphygmomanometer and the ECG monitor to judge the accuracy. The subjects were enrolled from October 2022 to February 2023 patients who underwent in-patient peritoneal dialysis or outpatient follow-up in the Department of Nephrology of a third-class A hospital in Nanjing and were dialysis age≥1 week. The patient's demographic and clinical information were collected. Record the abdominal pressure values of patients with different doses and different positions, measure the incidence of symptoms such as pain and abdominal distension, pressure-related complications and infections after intra-abdominal pressure. Follow up outcomes 3 months after intra-abdominal pressure measurement.The consistency of the two manometry methods was evaluated by intra-group correlation coefficient.A scatter plot and Spearman correlation test were used to explore the correlation between fill volumes and the intraperitoneal pressure.
Ｒｅｓｕｌｔｓ：The pressure value of the ECG monitor is almost the same as that of the mercury sphygmomanometer. The pressure value of the U-shaped pressure gauge after conversion is in good consistency with that of the mercury pressure with high reliability (ICC=0.997, P<0.001). Fifty-one patients were included in this study, and the measurement results showed that the abdominal pressure increased with the increase of the amount of peritoneal dialysis fluid in the same body position. Under the same amount of peritoneal dialysis fluid, the abdominal pressure value was in upright position> sitting position> lying position. The increase of abdominal pressure was positively correlated with the increase of peritoneal perfusion in three different postures (decubitus: r=0.777, P<0.001; Sitting position: r=0.809, P<0.001; Upright position: r=0.740, P<0.001). 1 patient showed transient mild pain in the shoulder and back during the manometry, while the rest patients showed no discomfort and no signs and symptoms of peritonitis during the measurement. After one month of observation, none of the 51 patients developed manometry related peritonitis and pressure related abdominal hernia.
Ｃｏｎｃｌｕｓｉｏｎ：This device has accurate measurement and safe use process, and can be reused and measured intra-abdominal pressure, which is instructive for the formulation of clinical dialysis prescription in patients with abdominal dialysis.

Key words: peritoneal dialysis, abdominal cavity, pressure, equipment design, feasibility