Abstract: Coronary microvascular dysfunction is a clinical syndrome in which angina pectoris occurs without obstructive coronary heart disease and the electrocardiogram shows ischemic changes. The main pathophysiological mechanisms are structural, functional and extravascular changes. Coronary microvascular dysfunction can be assessed and diagnosed by non-invasive methods such as positron emission tomography and invasive methods such as vascular catheters with special sensors. In chronic kidney disease patients, hypertension, proteinuria, uremic toxins, anemia, mineral metabolism disorders, and chronic inflammation state lead to coronary microvascular remodeling and endothelial dysfunction through a series of special mechanisms, thereby causing coronary microvascular disfunction.

Key words: chronic kidney disease, coronary microvascular disease, pathophysiologydiagnosis