Abstract: Diabetic kidney disease(DKD) is one of the main complications of diabetes mellitus because there is no effective treatment,many DKD progressed to ESRD,bring heavy burden for in dividuals and society.There has been an explosion of studies on the treatment regarding mechanisms and drugs in recent years.We reviewed latest researches on sodiumglucose cotransporter2 inhibitor,glucagonlike peptide1 receptor agonist,dipeptidyl peptidase4 inhibitor,protein kinaseC inhibitor,advanced glycation end products inhibitor,mineralocorticoid receptor antagonist,as well as uptodate therapies inhibiting oxidative stress,inflammation and fibrosis so that clinicians could have a reference on the treatment of DKD.