Abstract: As the major complication of diabetes,diabetic nephropathy is also the major cause of  progression from chronic kidney disease to end stage renal disease.However,the incidence of nonproteinuria diabetic nephropathy（NPDN）in patients with type 2 diabetes is gradually increasing,causing vascular complications and renal function decrease.Therefore,understanding the pathogenesis,diagnostic markers and therapies of NPDN is the basis of effective treatment of diabetic nephropathy.