Abstract: Ｏｂｊｅｃｔｉｖｅ：To evaluate the impact of diabetes among hemodialysis patients with the analysis of intradialytic and interdialytic heart rate variability.
Ｍｅｔｈｏｄｏｌｏｇｙ：This study was carried out in the Hemodialysis Center of Peking University People’s Hospital between October 1， 2021 and December 31， 2022. HRV were measured at the beginning of hemodialysis， lasted for 28 hours or above. We compared heart rate variability of each hour （1h， 2h， 3h， 4h， 5h， 28h） between diabetic and non-diabetic groups.
Ｒｅｓｕｌｔｓ：One hundred and ten patients were enrolled， included 36 diabetic patients （32.73%）. Diabetic HD patients had higher proportion of coronary artery disease， shorter dialysis vintage and lower spKt／V. Intradialytic HRV showed that diabetic patients had lower SDNN and LF than non-diabetic patients（P<0.05）. RMSSD of diabetic HD patients decreased throughout the HD process， non-diabetic patients increased gradually， neither changes reached significant level. RMSSD was significantly different between diabetic and non-diabetic groups after first hour of HD. Diabetic group had significantly lower SDNN-5 and LF-5. Diabetes was not associated with differences in any HRV-28 parameter. SDNN-28、RMSSD-28、LF-28、HRV-28 decreased dramatically in non-diabetic patients.
Ｃｏｎｃｌｕｓｉｏｎ：The impact of diabetic outstood the influence of uremic autonomic dysfunction in maintenance hemodialysis patients. Cardiac autonomic function of non-diabetic HD patients obviously compensated.

Key words: hemodialysis, diabetes, heart rate variability, cardiac autonomic dysfunction