Abstract: Lysosome is an organelle in eukaryotes responsible for degrading intracellular substances and maintaining cell homeostasis. Previous studies have shown that lysosomes have not only the function of degradation, but also the functions of exocytosis of proteins and vesicles, plasma membrane repair and remodeling, autophagy, regulation of lipid metabolism and immunity. Lysosomes are present in all eukaryotic cells, including glomerular cells. Recent studies have shown that lysosomes are abundant in glomerular cells, and that their dysfunction can cause a variety of glomerular diseases. This paper reviews three aspects of lysosomal function, the relationship between lysosomes and glomerular cells, and lysosomal dysfunction in glomerular disease, thus providing new ideas for future research on the mechanisms of glomerular disease.

Key words: lysosome, biological function, glomerular disease