Abstract: Monoclonal gammopathy is a group of diseases characterized as clonal plasma cell proliferation and monoclonal immunoglobin secretion. This kind of diseases include systemic light chain amyloidosis, multiple myeloma, monoclonal gammopathy of renal significance and monoclonal gammopathy of undetermined significance which was considered as the previous stage of these diseases. Kidney is frequently involved in these diseases. Immune microenvironment plays an important role in the emergence and progression of these diseases. Immune cells such as T cells, B cells, monocytes and macrophages, natural killer cells, dendritic cells and myeloid-derived suppressor cells interact with clonal plasma cells, thereby regulate the clearance of these plasma cells, maintain the balance of immune microenvironment and plasma cells, and the immune evasion of clonal plasma cells. We are going to review the immune microenvironment and the therapies targeted the immune system in monoclonal gammopathy.

Key words: monoclonal gammopathy, systemic light chain amyloidosis, multiple myeloma, immune microenvironment, treatment