Abstract:

FcγRs are members of the immunoglobulin superfamily of proteins and are found on many haematopoietic lineages. FcγRⅡB is a singlechain molecule that contains an immunereceptor tyrosinebased inhibitory motif (ITIM) in its cytoplasmic domain. FcγRⅡB dysfunction can result in systemic autoimmune diseases,such as systemic lupus erythematosus,Kawasaki disease and Ankylosing Spondylitis. This review is focus on recent studies on the correlation of FcγRⅡBI232T polymorphisms with susceptibility,activity and treatment response of autoimmune disease.

Key words: Fc fragment of IgG receptor, single nucleotide polymorphism, autoimmune disease