Abstract:

Membranous nephropathy (MN) is an organspecific autoimmune disease.Thrombospondin type 1 domaincontaining 7A (THSD7A) is a new firmly recognized target antigen of MN.THSD7A antibody can induce podocyte injury and proteinuria by binding to THSD7A antigen on the surface of  podocyte.Though the discovery of THSD7A was more recent,limited data has addressed the role of THSD7A antibody in diagnosis,prognosis and monitor  of MN.In addition,we can use the mice model to study the pathogenesis of THSD7Aassociated MN because of the high expression of THSD7A on both human and murine podocyte.This review focused on the main discoveries and current knowledge of THSD7A and MN.

Key words: thrombospondin type 1 domaincontaining 7A, membranous nephropathy, podocyte injuryphos, pholipase A2 receptor