Abstract: This case reports one 34-year-old female patient who was admitted to the hospital with “nausea and vomiting for more than a month， gross hematuria with elevated serum creatinine for more than 20 days”. The patient was diagnosed with COVID-19 infection and gastroenteritis in the local hospital prior to admission. Subsequently，the patient developed gross hematuria， decreased urine output with anemia， thrombocytopenia， progressive elevation of serum creatinine requiring renal replacement therapy， positive anti-glomerular basement membrane （GBM） antibody， and positive platelet-specific antibodies. Renal biopsy was anti-GBM nephritis. After being given anti-infective drugs， glucocorticoids， rituximab， cyclophosphamide and protein A immunoadsorption therapy， the patient's condition improved and she withdrew from dialysis.

Key words: COVID-19, anti-glomerular basement membrane nephritis, immune thrombocytopenia