Abstract: A 42-year-old man presented with nephroticrange proteinuria and hematuria, renal dysfunction, hypertension, decreased serum C3, anemia, elevated κ/λ ratio, 8％ plasmacytosis in bone marrow biopsy. Kidney biopsy showed proliferative glomerulonephritis with nodular pattern. Immunoflurerscence indicated restricted κ light chain and C3 distributed in glomerular capillary wall and mesangial with granular appearance. The electrondense deposits without substructure were identified predominately in subendothelial,mesangial and occasional in subepithelial region by electron microscopy. The final diagnosis was light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits.

Key words: light chain, monoclonal immunoglobulin, proliferative glomerulonephritis with monoclonal immunoglobulin deposits