Abstract: 48yearold woman was diagnosed as kappa light chain amyloidosis with kidney and heart involvement.Bone marrow biopsy revealed 25％ plasma cells and FISH analysis showed gain of 1q21 and translocation t(11;14).A combination of bortezomib and dexamethasone was initiated but after 7 cycles,she developed progressive disease and therapy was switched to highdose melphalan and autologous stem cell transplantation (ASCT).She achieved a very good partial response (VGPR) at day 30.However her serum kappa light chain increased 4 months after ASCT and treatment with BD was restarted.Her best hematologic response was PR as ever,and lasted for only 5 months.Then she was treated with daratumumab and dexamethasone weekly for 4 weeks.She achieved VGPR after the 1st week and complete remission (CR) after the 4th weeks.After an interval of 1 month she proceed with another 4 doses of daratumumab every other week and remained hematologic CR during the followup,without renal response.

Key words: light chain amyloidosis, relapsed, daratumumab