Abstract: Vascular calcification is one of the most common complications and the main factor affecting prognosis of patients with chronic kidney disease. Early diagnosis, accurate evaluation and timely intervention on vascular calcification are crucial to improve prognosis of vascular calcification patients. A number of studies on serum biomarkers of vascular calcification were performed and got hopeful results. The current manuscript will review some biomarkers, such as matrix GlaProtein(MGP),osteocalcin(OC),pyrophosphate(PPi),osteoprotegerin(OPG),fibroblast growth factor23(FGF23),klotho protein, calciprotein particle(CCP),sclerostin and dickkopf1 (Dkk1), in order to provide significance for diagnosis and treatment of vascular calcification in patients with chronic kidney disease.

Key words: chronic kidney disease,vascular calcification,biomarkers