Abstract: Antiphospholipid syndrome(APS), which can present with a variety of clinical phenotypes, including thromboembolism related events and morbid pregnancy, is a kind of autoimmune disease assiociated with antiphospholipid antibodies (aPLs). The traditional antibodies in the diagonostics of APS are lupus anticoagulant, anticardiolipin antibody and β2glycoproteinⅠ antibody. However some patients are still highly suspected of antiphospholipid syndrome, but the above three standard antibodies are negative. In current, studies have shown that many other antibodies related to phospholipid components can also be found in patients with antiphospholipid syndrome, and have certain clinical diagnostic value. This article reviews the potential antibodies associated with antiphospholipid antibody syndrome and their clinical application.

Key words: antiphospholipid syndrome,antiphospholipid antibodies,diagnosis