Abstract: Ｏｂｊｅｃｔｉｖｅ：Previous studies have found the maturity rate of radiocephalic arteriovenous fistula(RCAVF) in elderly patients is low.The objective of the study was to perform trend analysis to verify relationship between increasing age and functional maturation of RCAVF.
Ｍｅｔｈｏｄｏｌｏｇｙ：Our retrospective cohort study enrolled and analyzed 265 followup cases underging first AVF creation.The artery and vein sizes were measured by ultrasound.After surgery,we performed a followup minimum of 3 monthsMultivariable logistic regression analysis was to identify whether age was an independent risk factor of maturation.Participants were categorized into four groups(Age≤29y,30～49y,50～69y,and 70～89y)We adjusted  some confounders in four logistic models and primary analyses were based on building ordered age categories models and tested P values for trends to estimate the relationship between each 20 years increase in age and immaturity risk of RCAVF.
Ｒｅｓｕｌｔｓ：46 weeks after the surgery,the  wrist RCAVF mature group included 218 cases,and immature group included 47 casesOdds ratios（OR）value associated with immaturity rate were reduced with increasing age,and P values for trend(＜005) were all observed in four different models.Each 20 years increase in age was significantly associated with higher incidence of immaturity odds ratios(OR values more than 16) after adjusting multivariate models.The smooth curves for the relationship between increasing age and immaturity were shown.
Ｃｏｎｃｌｕｓｉｏｎ：
This study suggested that significantly higher immaturity risk of wrist RCAVF associated with exposure to age.Linear exposureresponse relations between age  and incident immaturity was proved.For every 20 years of age the risk of immaturity increases by more than 60%.

Key words: wrist radio-cephalic arteriovenous fistula, functional maturation, age