Abstract: Ｏｂｊｅｃｔｉｖｅ：To investigate the clinical manifestations and prognosis of patients with lupus nephritis (LN) and lupus myocarditis (LM), and properties of cardiac magnetic resonance (CMR).
Ｍｅｔｈｏｄｏｌｏｇｙ：Sixtysix patients, 61 women and 5 men, with a median onset age of 29 (21,39) years,were diagnosed with LN and LM from October 2016 to March 2019. The diagnosis for LM was based on clinical manifestations, EKG, troponin and ultrasonic cardiogram (UCG), or CMR. Clinical manifestations and prognosis of patients with LN and LM were studied, and the application of CMR in LM early diagnosis was evaluated.
Ｒｅｓｕｌｔｓ：55(833%) suffered form AKI, 42(636%) needed renal replacement therapy.46 underwent renal biopsy, 39 showed LN class Ⅳ or Ⅳ+Ⅴ. 24 (522%) biopsy showed thrombotic microangiopathy. 22(333%) of them had LM as their initial presentation of Systemic Lupus Erythematosus. Symptoms of myocarditis consisted of dyspnea(758%), palpitation(273%) and chest pain(106%) . NTproBNP and troponin were increased in 59(894%) and 15(227%) patients. UCG showed left ventricular enlargement in 32(485%), ventricular wall thickening in 15(227%), abnormal left ventricular wall motion in 14(212%), 41(621%) met UCG criteria. 63 underwent CMR, 31(492%) met the LakeLouise criteria. T1 values＞1 370 ms in 49(778%) patients. Indicators of cardiac injury were more serious in LM patients with AKI.60 cases received methylprednisolone venous therapy, 24 received gamma globulin and dual plasmaphermoplasty. After median followup of 75 months, only 21(500%) patients weaned of dialysis, 2 patients died of infection. 4 cases progressed to chronic cardiac insufficiency.
Ｃｏｎｃｌｕｓｉｏｎ：
LM patients with AKI  had more serious damage of heart function.Compare to the poor renal prognosis, most of LM patients recovered from heart injury after treatment.Application of CMR T1Mapping can improve sensitivity of LM early diagnosis

Key words: lupus myocarditis, lupus nephritis, cardiac magnetic resonance, T1-Mapping