ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2016, Vol. 25 ›› Issue (3): 291-295.

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Gitelman综合征肾脏损害

  

  • 出版日期:2016-06-28 发布日期:2016-07-04

Renal Impairment in Gitelman's Syndrome

  • Online:2016-06-28 Published:2016-07-04

摘要:

摘 要 青年女性,临床表现为反复四肢无力,血压偏低,伴低血钾、代谢性碱中毒、血镁正常、肾素-血管紧张素Ⅱ-醛固酮系统 ( RAAS)激活、血清肌酐升高、低尿钙,24h尿蛋白定量及尿沉渣红细胞计数均在正常范围。肾活检示肾小球球旁器肥大,肾小管间质重度慢性病变合并轻度急性病变。最终诊断Gitelman 综合征相关肾损害。

关键词: Gitelman综合征, 肾小球球旁器, 肾活检

Abstract:

Abstract: A 31-year-old woman with recurrent weakness in the limbs and hypotension or normotension was admitted our hospital. Blood tests demonstrated elevated serum creatinine, hypokalemic hypochloremic metabolic alkalosis, normomagnesemia and elevated levels of renin and aldosterone. Urinalysis revealed renal loss of potassium and hypocalciuria. There was no proteinuria or hematuria. Renal biopsy showed hyperplasia of juxtaglomerular apparatus, severe interstitial fibrosis and tubular atrophy and mild acute tubular injury. Finally, we considered the renal impairment in the patient was related to Gitelman’s syndrome.
Key words

Key words: Gitelman’s syndrome, juxtaglomerular apparatus, Renal biopsy