关键词:  肾移植, 横纹肌溶解症, 急性肾功能衰竭, 器官捐献

Abstract:

【Abstract】Objectives: To explore the clinical effect of kidney transplantation from donors with acute kidney injury (AKI) and rhabdomyolysis. Methodology: Kidney transplantation from donors with AKI and rhabdomyolysis from January 2012 to December 2015 was retrospectively reviewed. AKI was defined by RIFLE criteria. Rhabdomyolysis was defined by creatinine kinase (CK) level higher than five times normal (＞ 1000U/L) in conjunction with high serum myoblobin. Results: Eight donors suffered from rhabdomyolysis and AKI with peak CK 10623 ± 3692U/L, peak serum myoblobin 20618 ± 7959μg/L and peak serum creatinine 483 ± 176μmol/L. 3 donors received plasmapheresis therapy (1～2 sessions), 2 donors received continuous renal replacement therapy and one received extra-corporeal membrane oxygenation treatment. In 16 recipients from these donors, there were 4 cases (25.0%) with delayed graft function, 4 cases with slow graft function and 8 cases with normal graft function. Within a follow-up of 6 - 46 months, all patients and renal grafts were survived. Mean 6 and 12-month glomerular filtration rate were 65.4 ± 13.5 and 71.2 ± 14.3 mL/(min•1.73m2) respectively. Conclusions: The recipients from donors with AKI and rhabdomyolysis had excellent short-term outcomes. Routine Screening for rhabdomyolysis should be recommended in deceased donors with acute renal injury.

Key words: kidney transplantation, rhabdomyolysis, acute renal failure, organ donation