关键词: 腹膜透析, 缺血修饰白蛋白, 心血管事件

Abstract:

Ｏｂｊｅｃｔｉｖｅ：To evaluate the impact factor of ischemia modified albumin （IMA） in patients on peritoneal dialysis.
Ｍｅｔｈｏｄｏｌｏｇｙ：A total of one hundred fifty eight patients on peritoneal dialysis over 3 months, who were 82 males and 76 females with the average ages of 461±118 years old, were enrolled in this study. Baseline characteristics, IMA levels and other laboratory measurements were collected and analyzed. According to IMA level, the patients were divided into high IMA group (IMA≥8556 KU/L, n=52) and normal IMA group (IMA<8556 KU/L, n=106).
Ｒｅｓｕｌｔｓ：In high IMA group, the levels of serum albumin, residual renal function and total creatinine clearance rate were significantly lower than those in normal IMA group. Multivariable logistic regression analysis results showed that levels of serum albumin and total creatinine clearance rate were impact factors for IMA. Subgroup analysis was also carried out. IMA and major adverse cardiovascular events in the subgroups of serum albumin＜30 g/L were significantly higher than in the other three subgroups. The patients in the subgroup of total creatinine clearance rate<60 L/(W·173m2), had significantly higher level of IMA and MACE.
Ｃｏｎｃｌｕｓｉｏｎ：The levels of serum albumin and total creatinine clearance were the important factors influencing the IMA in PD patients. Improve nutritional status, protection of residual renal function, increasing peritoneal dialysis adequacy could be very important to reduce the happening of cardiovascular events.