Abstract:

【Abstract】 In the kidney, microvascular pericytes are extensively branched, collagen-producing cells in close contact with endothelial cells. These cells contribute to the stability of microvascular in physiological condition. After continuous renal injury, the pericytes detach from the basement of capillaries and transform to scar-forming myofibroblasts. Inhibit pericyte-myofibroblasts transforming improve the renal fibrosis and peritubular capillary rarefaction. Additionally, the pericyte may be the major erythropoietin-producing cell in the kidney. In the patients of chronic kidney disease, transforming to myofibroblast make the pericyte effectiveless in producing the erythropoietin although the marked anemia. The research about the pericyte in kidney has made great process in recent years. Learning about the function of pericyte help us to understand the mechanism of renal fibrosis. Furthermore, the therapy targeting the pericyte may be helpful in preventing the progress of renal fibrosis.