关键词: 腹膜透析, 腹主动脉, 钙质沉着症, 可溶性klotho

Abstract:

【Abstract】Objective: To investigate the clinic feature of peritoneal dialysis (PD) patients with abdominal aortic calcification, and to analyze the relationship between the levels of serum soluble Klotho protein (sKL) and abdominal aortic calcification. Methodology: Eighty patients with continuous ambulatory peritoneal dialysis（CAPD）, who dialysis regularly for more than 3 months, were collected prospectively. The levels of serum sKL and Fibroblast growth factor 23 (FGF23) were detected by ELISA. Abdomen 1ateral plain was used as a criterion to determine the abdominal aorticcal cification. The abdominal aortic calcification score (AAC) was calculated. Logistic regression analysis was used to determine the risk factor of abdominal aortic calcification in PD patients. The ROC analysis was applied to evaluate the predict value of sKL in abdominal aortic calcification. Results: The abdominal aortic calcification was found in 41（ 51.3%）patients, which was most severe in front of the fourth lumbar segment and ameliorated in higher lumbar levels. The sKL concentration was negatively correlated with AAC, and no correlation with FGF23. Logistic regression analysis showed that lower serum sKL level（OR=0.969, 95％CI 0.947～0.991, P＜0.01）and higher age（OR=1.115, 95％CI 1.044～1.191, P＜0.01）were independent risk factors for moderate to severe calcification of the abdominal aorta．ROC-AUC of serum sKL for moderate to severe abdominal aortic calcification was O.800 (cut off 361.50pg/ml，accuracy 71.4％，specificity 84.6％). Conclusions: The lower serum sKL is significantly associated with abdominal aorta calcification. Serum sKL may play an important role in the mechanism of abdominal aortic calcification in PD patients.

Key words: Peritoneal dialysis, abdominal aortic calcification, Calcinosis, Soluble Klotho